Google
Trusted Resources: News & Events
Latest announcements and gatherings
More Curative Bone Marrow Transplants are Successful When Patients Given Double the Radiation Beforehand, Study Says
The success rate of bone marrow transplants for patients with sickle cell disease or beta thalassemia, from only “half-matched” donors, increased by doubling the radiation delivered to patients’ bodies before the transplants, a John Hopkins University study shows.
The study, “Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial,” was published in the journal The Lancet Haematology.
Sickle cell disease can potentially be cured with bone marrow transplants, but the strategy has been of limited use due to some constraints, namely the need to match the donor and the recipient for protein markers called human leukocyte antigens (HLA), a set of proteins that can trigger an immune system response. Each person carries a unique set of these proteins, which means that matching potential organ donors and recipients requires thorough testing to check that their HLAs are compatible.
+myBinderRelated Content
-
More Cures for More Patients Through Sickle Cell Research: Courtney Fitzhugh, MDhttps://www.youtube.com/watch?v=OvdpT1Dn...
-
Sickle Cell Breakthrough: Shauna’s Storyhttps://www.youtube.com/watch?v=Q-kXWV-s...
-
The Family Perspectivehttp://www.sicklecelltransplantconsortiu...
-
A Multicenter Phase II Trial of Unrelated Donor Reduced Intensity Bone Marrow Transplantation for Children with Seve...Background: Children with severe sickle...
-
Family Celebrates 7-Year-Old’s Sickle Cell Cure Thanks to Sister’s Life-Saving GiftOne 7-year-old who suffered his whole li...
-
A Child Prodigy, a Painful Disease, and a Life-Changing Treatmenthttps://www.youtube.com/watch?v=SpzjD1ct...
-
Pain and opioid use after reversal of sickle cell disease following hematopoietic stem cell transplantPain is the most common symptom of sickl...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
Support for this site is provided by
This platform is made possible through a partnership with the Sickle Cell Disease Association of America, Inc. (SCDAA) and its member organizations. SCDAA's mission is to advocate for people affected by sickle cell conditions and empower community-based organizations to maximize quality of life and raise public consciousness while advancing the search for a universal cure.